منابع مشابه
Paraoxonase and atherosclerosis.
There is considerable evidence that the antioxidant activity of high density lipoprotein (HDL) is largely due to the paraoxonase-1 (PON1) located on it. Experiments with transgenic PON1 knockout mice indicate the potential for PON1 to protect against atherogenesis. This protective effect of HDL against low density lipoprotein (LDL) lipid peroxidation is maintained longer than is the protective ...
متن کاملA Brief Review of the Association between Genetic Polymorphisms of the Paraoxonase Family and Atherosclerosis
Atherosclerosis is known as an inflammatory disease that can affect any vessel in the body. The occurrence of atherosclerosis in heart vessels is called coronary artery disease (CAD). CAD is one of the most significant causes of morbidity and mortality in developed countries. Different genetic and environmental factors can cause cardiovascular diseases, such as age, weight, sex, and low high-de...
متن کاملDecreased obesity and atherosclerosis in human paraoxonase 3 transgenic mice.
Paraoxonase 3 (PON3) is a member of the PON family, which includes PON1, PON2, and PON3. Recently, PON3 was shown to prevent the oxidation of low-density lipoprotein in vitro. To test the role of PON3 in atherosclerosis and related traits, 2 independent lines of human PON3 transgenic (Tg) mice on the C57BL/6J (B6) background were constructed. Human PON3 mRNA was detected in various tissues, inc...
متن کاملIs paraoxonase-3 another hdl-associated protein protective against atherosclerosis?
Investigations on mammalian serum paraoxonase (PON), now called PON1, started nearly 50 years ago by Aldridge2,3 with the study of its hydrolytic activity with paraoxon and other organophosphates. More recently, '5 years ago, it was established that PON1 is a member multigene family in mammals.4 There are 3 PON genes closely aligned on human chromosome 7 and mouse chromosome 6. Research efforts...
متن کاملPARAOXONASE AND ARYLESTERASE ACTIVITY AMONG HYPERCHOLESTEROLEMIC PATIENTS
Human serum paraoxonase (PON) associated with high density lipoprotein (HDL) , has been postulated to have a role in protecting low-density lipoprotein (LDL) against oxidative damage, which has led to the proposal that PON is an anti-atherogenic and anti-inflammatory enzyme. It has genetic polymorphism at the 191 (R ->Q) and two alloenzymes A and B and three phenotypes A, B, and AB. We exa...
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ژورنال
عنوان ژورنال: Arteriosclerosis, Thrombosis, and Vascular Biology
سال: 2001
ISSN: 1079-5642,1524-4636
DOI: 10.1161/01.atv.21.4.473